Issue 32, 2015
From the journal:

Chemical Communications

A firmly hybridizable, DNA-like architecture with DAD/ADA- and ADD/DAA-type nonnatural base pairs as an extracellular genetic candidate†

Wataru Shirato,a   Junya Chiba*a  and  Masahiko Inouye*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Japan
E-mail: chiba@pha.u-toyama.ac.jp, inouye@pha.u-toyama.ac.jp

Abstract

We describe artificial DNA molecules exclusively consisting of four types of alkynyl C-nucleotides with nonnatural bases. The artificial DNA exhibited almost the same characteristics as natural DNA, such as in regard to the stepwise duplex and triplex formation and the right-handed higher-order structure with an antiparallel alignment fashion.

Graphical abstract: A firmly hybridizable, DNA-like architecture with DAD/ADA- and ADD/DAA-type nonnatural base pairs as an extracellular genetic candidate

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Article information

DOI
https://doi.org/10.1039/C4CC09486G
Article type
Communication
Submitted
27 Nov 2014
Accepted
12 Mar 2015
First published
12 Mar 2015

Chem. Commun., 2015,51, 7043-7046

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A firmly hybridizable, DNA-like architecture with DAD/ADA- and ADD/DAA-type nonnatural base pairs as an extracellular genetic candidate

W. Shirato, J. Chiba and M. Inouye, Chem. Commun., 2015, 51, 7043 DOI: 10.1039/C4CC09486G

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