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Issue 30, 2015
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Acyclicl-threoninol nucleic acid (l-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

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Abstract

We report the hybridization properties of a novel artificial nucleic acid: acyclicL-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.

Graphical abstract: Acyclic l-threoninol nucleic acid (l-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

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Article information


Submitted
19 Nov 2014
Accepted
05 Jan 2015
First published
30 Jan 2015

Chem. Commun., 2015,51, 6500-6503
Article type
Communication
Author version available

Acyclic L-threoninol nucleic acid (L-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

K. Murayama, H. Kashida and H. Asanuma, Chem. Commun., 2015, 51, 6500
DOI: 10.1039/C4CC09244A

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