Issue 11, 2015
From the journal:

Chemical Communications

Ultrasensitive electrochemical detection of breast cancer cells based on DNA-rolling-circle-amplification-directed enzyme-catalyzed polymerization†

Qinglin Sheng,a   Ni Cheng,a   Wushuang Baia  and  Jianbin Zheng*a  

* Corresponding authors

a Institute of Analytical Science/Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an, Shaanxi 710069, China
E-mail: zhengjb@nwu.edu.cn
Fax: +86-29-88303448
Tel: +86-29-88303448

Abstract

An ultrasensitive cytosensor based on DNA-rolling-circle-amplification-directed enzyme-catalyzed polymerization is demonstrated. As a proof of concept, the cytosensor shows excellent sensitivity for MCF-7 cell detection with a lower detection limit of 12 cells per mL.

Graphical abstract: Ultrasensitive electrochemical detection of breast cancer cells based on DNA-rolling-circle-amplification-directed enzyme-catalyzed polymerization

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Article information

DOI
https://doi.org/10.1039/C4CC08954E
Article type
Communication
Submitted
10 Nov 2014
Accepted
02 Dec 2014
First published
03 Dec 2014

Chem. Commun., 2015,51, 2114-2117

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Ultrasensitive electrochemical detection of breast cancer cells based on DNA-rolling-circle-amplification-directed enzyme-catalyzed polymerization

Q. Sheng, N. Cheng, W. Bai and J. Zheng, Chem. Commun., 2015, 51, 2114 DOI: 10.1039/C4CC08954E

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