Issue 15, 2015
From the journal:

Chemical Communications

Synthesis of polyfunctional secondary amines by the addition of functionalized zinc reagents to nitrosoarenes†

Vasudevan Dhayalan,a   Christoph Sämanna  and  Paul Knochel*a  

* Corresponding authors

a Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany
E-mail: paul.knochel@cup.uni-muenchen.de
Fax: +49-(0)89-2180-77680
Tel: +49-(0)89-2180-77679

Abstract

Addition of functionalized aryl, heteroaryl or adamantyl zinc reagents to various nitroso-arenes in the presence of magnesium salts and LiCl in THF produces after a reductive work-up with FeCl2 and NaBH4 in ethanol the corresponding polyfunctional secondary amines in high yields.

Graphical abstract: Synthesis of polyfunctional secondary amines by the addition of functionalized zinc reagents to nitrosoarenes

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Article information

DOI
https://doi.org/10.1039/C4CC08846H
Article type
Communication
Submitted
05 Nov 2014
Accepted
09 Jan 2015
First published
09 Jan 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 3239-3242

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Synthesis of polyfunctional secondary amines by the addition of functionalized zinc reagents to nitrosoarenes

V. Dhayalan, C. Sämann and P. Knochel, Chem. Commun., 2015, 51, 3239 DOI: 10.1039/C4CC08846H

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