Issue 8, 2015
From the journal:

Chemical Communications

Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapy†

Ming Kong,*a   Lin Hou,a   Juan Wang,a   Chao Feng,a   Ya Liu,a   Xiaojie Chenga  and  Xiguang Chen*a  

* Corresponding authors

a Biochemistry and biomaterial key laboratory of Shandong colleges and universities, College of Marine Life Science, Ocean University of China, Yushan Road, Qingdao, China
E-mail: kongming@ouc.edu.cn, xgchen@ouc.edu.cn
Tel: +86-532-83022879

Abstract

A novel hyaluronic acid modified transfersome was prepared to deliver drugs to lymphatics through the transdermal route. Doxorubicin loaded HA-GMS-T was able to efficiently penetrate into the deep skin tissue, leading to enhanced absorption by lymphatics. Most importantly, hyaluronic acid effectively improved the uptake of drug loaded nanocarriers by tumor cells.

Graphical abstract: Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapy

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Article information

DOI
https://doi.org/10.1039/C4CC08746A
Article type
Communication
Submitted
03 Nov 2014
Accepted
24 Nov 2014
First published
08 Dec 2014

Chem. Commun., 2015,51, 1453-1456

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Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapy

M. Kong, L. Hou, J. Wang, C. Feng, Y. Liu, X. Cheng and X. Chen, Chem. Commun., 2015, 51, 1453 DOI: 10.1039/C4CC08746A

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