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Issue 7, 2015
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Krebs cycle metabolon formation: metabolite concentration gradient enhanced compartmentation of sequential enzymes

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Abstract

Dynamics of metabolon formation in mitochondria was probed by studying diffusional motion of two sequential Krebs cycle enzymes in a microfluidic channel. Enhanced directional co-diffusion of both enzymes against a substrate concentration gradient was observed in the presence of intermediate generation. This reveals a metabolite directed compartmentation of metabolic pathways.

Graphical abstract: Krebs cycle metabolon formation: metabolite concentration gradient enhanced compartmentation of sequential enzymes

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Article information


Submitted
01 Nov 2014
Accepted
28 Nov 2014
First published
28 Nov 2014

Chem. Commun., 2015,51, 1244-1247
Article type
Communication

Krebs cycle metabolon formation: metabolite concentration gradient enhanced compartmentation of sequential enzymes

F. Wu, L. N. Pelster and S. D. Minteer, Chem. Commun., 2015, 51, 1244
DOI: 10.1039/C4CC08702J

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