Issue 2, 2015

A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes

Abstract

An easily available BINOL–Ti(OiPr)4 catalyst system is found to activate the reaction of Zn powder with EtI for the asymmetric alkyne addition to aldehydes at room temperature. It allows the synthesis of a number of synthetically useful chiral propargylic alcohols with both high yields and high enantioselectivity (up to >96% ee).

Graphical abstract: A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
10 Oct 2014
Accepted
07 Nov 2014
First published
10 Nov 2014

Chem. Commun., 2015,51, 358-361

Author version available

A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes

S. Chen, W. Liu, X. Wu, J. Ying, X. Yu and L. Pu, Chem. Commun., 2015, 51, 358 DOI: 10.1039/C4CC08031A

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