Jump to main content
Jump to site search

Issue 16, 2015
Previous Article Next Article

Highly sensitive detection of CpG methylation in genomic DNA by AuNP-based colorimetric assay with ligase chain reaction

Author affiliations

Abstract

We have developed a new ligase chain reaction-based colorimetric assay for detection of DNA methylation with ultrahigh sensitivity and selectivity. Using the proposed assay, as low as 0.01 fM methylated DNA can be detected by visualization of color changes of gold nanoparticles with the naked eye.

Graphical abstract: Highly sensitive detection of CpG methylation in genomic DNA by AuNP-based colorimetric assay with ligase chain reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Sep 2014, accepted on 19 Jan 2015 and first published on 19 Jan 2015


Article type: Communication
DOI: 10.1039/C4CC07688E
Chem. Commun., 2015,51, 3371-3374

  •   Request permissions

    Highly sensitive detection of CpG methylation in genomic DNA by AuNP-based colorimetric assay with ligase chain reaction

    F. Su, L. Wang, Y. Sun, C. Liu, X. Duan and Z. Li, Chem. Commun., 2015, 51, 3371
    DOI: 10.1039/C4CC07688E

Search articles by author

Spotlight

Advertisements