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Issue 3, 2015
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MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

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Abstract

Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.

Graphical abstract: MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

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Supplementary files

Article information


Submitted
25 Sep 2014
Accepted
07 Oct 2014
First published
07 Oct 2014

Chem. Commun., 2015,51, 465-468
Article type
Communication

MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

W. Chen, G. Luo, Q. Lei, H. Jia, S. Hong, Q. Wang, R. Zhuo and X. Zhang, Chem. Commun., 2015, 51, 465
DOI: 10.1039/C4CC07563C

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