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Issue 5, 2015
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Enantioselective synthesis of arylglycine derivatives by direct C–H oxidative cross-coupling

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Abstract

A new method for the synthesis of chiral α-amino acid derivatives by enantioselective C–H arylation of N-aryl glycine esters with aryl boric acids in the presence of a chiral Pd(II)-catalyst has been developed. This work successfully integrates the direct C–H oxidation with asymmetric arylation and exhibits excellent enantioselectivity.

Graphical abstract: Enantioselective synthesis of arylglycine derivatives by direct C–H oxidative cross-coupling

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Publication details

The article was received on 18 Sep 2014, accepted on 14 Oct 2014 and first published on 14 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC07361D
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Chem. Commun., 2015,51, 832-835

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    Enantioselective synthesis of arylglycine derivatives by direct C–H oxidative cross-coupling

    X. Wei, G. Wang and S. Yang, Chem. Commun., 2015, 51, 832
    DOI: 10.1039/C4CC07361D

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