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Issue 25, 2015
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Orthogonal selectivity with cinnamic acids in 3-substituted benzofuran synthesis through C–H olefination of phenols

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Abstract

A palladium catalyzed intermolecular annulation of cinnamic acids and phenols has been achieved for the selective synthesis of 3-substituted benzofurans. Isotope labeling, competition experiments, kinetic studies, and intermediate trapping have supported a sequence of C–C bond formation and decarboxylation followed by the C–O cyclization pathway.

Graphical abstract: Orthogonal selectivity with cinnamic acids in 3-substituted benzofuran synthesis through C–H olefination of phenols

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The article was received on 05 Sep 2014, accepted on 16 Oct 2014 and first published on 16 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC07026G
Chem. Commun., 2015,51, 5375-5378

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    Orthogonal selectivity with cinnamic acids in 3-substituted benzofuran synthesis through C–H olefination of phenols

    S. Agasti, U. Sharma, T. Naveen and D. Maiti, Chem. Commun., 2015, 51, 5375
    DOI: 10.1039/C4CC07026G

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