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Issue 7, 2015
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Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae

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Abstract

Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been approved by the FDA which directly mediate biofilm formation or persistence. Herein we report oxazine 25 as a highly potent inhibitor, disperser and in the presence of the appropriate antibiotic eradicator of V. cholerae biofilms.

Graphical abstract: Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae

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Publication details

The article was received on 10 Sep 2014, accepted on 27 Nov 2014 and first published on 05 Dec 2014


Article type: Communication
DOI: 10.1039/C4CC07003H
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Chem. Commun., 2015,51, 1305-1308
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    Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae

    C. J. A. Warner, A. T. Cheng, F. H. Yildiz and R. G. Linington, Chem. Commun., 2015, 51, 1305
    DOI: 10.1039/C4CC07003H

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