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Issue 95, 2014
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A disulfide polymerized protein crystal

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Abstract

The vDED coiled coil domain from human BAP29 was crystallized in dimeric and tetrameric forms. For the dimer, a disulfide bond was unexpectedly found to bridge a crystal contact, resulting in complete cross-linking along the c-axis. This indicates that it is in principle possible to design spontaneously polymerizing protein crystals.

Graphical abstract: A disulfide polymerized protein crystal

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Article information


Submitted
16 Sep 2014
Accepted
13 Oct 2014
First published
14 Oct 2014

Chem. Commun., 2014,50, 14995-14997
Article type
Communication
Author version available

A disulfide polymerized protein crystal

E. M. Quistgaard, Chem. Commun., 2014, 50, 14995
DOI: 10.1039/C4CC07326F

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