Issue 92, 2014
From the journal:

Chemical Communications

Highly diastereo- and enantioselective copper-catalyzed propargylic alkylation of acyclic ketone enamines for the construction of two vicinal stereocenters†

De-Yang Zhang,ab   Fu-Lin Zhu,ab   Ya-Hui Wang,a   Xin-Hu Hu,a   Song Chen,a   Chuan-Jin Houac  and  Xiang-Ping Hu*a  

* Corresponding authors

a Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
E-mail: xiangping@dicp.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, China

c Dalian Polytechnic University, 1 Qinggongyuan, Dalian 116034, China

Abstract

The first highly diastereo- and enantioselective propargylic alkylation of acyclic ketone enamines to form vicinal tertiary stereocenters has been reported by employing copper catalysis in combination with a bulky and structurally rigid tridentate ketimine P,N,N-ligand.

Graphical abstract: Highly diastereo- and enantioselective copper-catalyzed propargylic alkylation of acyclic ketone enamines for the construction of two vicinal stereocenters

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Article information

DOI
https://doi.org/10.1039/C4CC06863G
Article type
Communication
Submitted
31 Aug 2014
Accepted
29 Sep 2014
First published
29 Sep 2014

Chem. Commun., 2014,50, 14459-14462

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Highly diastereo- and enantioselective copper-catalyzed propargylic alkylation of acyclic ketone enamines for the construction of two vicinal stereocenters

D. Zhang, F. Zhu, Y. Wang, X. Hu, S. Chen, C. Hou and X. Hu, Chem. Commun., 2014, 50, 14459 DOI: 10.1039/C4CC06863G

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