Issue 94, 2014
From the journal:

Chemical Communications

Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates: facile access to the phthalide skeleton†

Lili Chen,a   Hongji Li,*a   Feng Yua  and  Lei Wang*ab  

* Corresponding authors

a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
E-mail: leiwang@chnu.edu.cn
Fax: +86-561-309-0518
Tel: +86-561-380-2069

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

Abstract

A new protocol for Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates was established, which allows efficient construction of the phthalide skeleton. Interestingly, this reaction underwent a decarboxylative process, in which only divinylation was observed, and the subsequent cyclization led to the formation of phthalides.

Graphical abstract: Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates: facile access to the phthalide skeleton

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Article information

DOI
https://doi.org/10.1039/C4CC06331G
Article type
Communication
Submitted
12 Aug 2014
Accepted
12 Sep 2014
First published
06 Oct 2014

Chem. Commun., 2014,50, 14866-14869

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Ru-catalyzed decarboxylative cyclization of mandelic acids with acrylates: facile access to the phthalide skeleton

L. Chen, H. Li, F. Yu and L. Wang, Chem. Commun., 2014, 50, 14866 DOI: 10.1039/C4CC06331G

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