Issue 99, 2014

In situ labelling chemistry of respiratory syncytial viruses by employing the biotinylated host-cell membrane protein for tracking the early stage of virus entry

Abstract

An in situ labelling strategy was proposed to produce quantum dot-labelled respiratory syncytial viruses (RSVs) by incorporating the biotinylated membrane protein of the host cells into mature virions, followed by conjugation with streptavidin modified quantum dots (SA-QDs), which has the advantages such as convenience, efficiency and minor influence on viral infectivity and thus could be successfully applied to track the early stage of virus entry.

Graphical abstract: In situ labelling chemistry of respiratory syncytial viruses by employing the biotinylated host-cell membrane protein for tracking the early stage of virus entry

Supplementary files

Article information

Article type
Communication
Submitted
10 Aug 2014
Accepted
28 Oct 2014
First published
28 Oct 2014

Chem. Commun., 2014,50, 15776-15779

Author version available

In situ labelling chemistry of respiratory syncytial viruses by employing the biotinylated host-cell membrane protein for tracking the early stage of virus entry

L. L. Zheng, X. X. Yang, Y. Liu, X. Y. Wan, W. B. Wu, T. T. Wang, Q. Wang, S. J. Zhen and C. Z. Huang, Chem. Commun., 2014, 50, 15776 DOI: 10.1039/C4CC06264G

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