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Issue 90, 2014
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Electrochemically driven drug metabolism via a CYP1A2–UGT1A10 bienzyme confined in a graphene nano-cage

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Abstract

A graphene nano-cage with regulatable space for the assembly of a cytochrome P450 1A2–UDP-glucuronosyltransferase 1A10 bienzyme complex has been constructed via a click reaction, and successfully used to study drug sequential metabolism using an electrochemically-driven method.

Graphical abstract: Electrochemically driven drug metabolism via a CYP1A2–UGT1A10 bienzyme confined in a graphene nano-cage

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Publication details

The article was received on 08 Aug 2014, accepted on 08 Sep 2014 and first published on 08 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC06200K
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Chem. Commun., 2014,50, 13896-13899

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    Electrochemically driven drug metabolism via a CYP1A2–UGT1A10 bienzyme confined in a graphene nano-cage

    J. Lu, Y. Zhang, H. Li, J. Yu and S. Liu, Chem. Commun., 2014, 50, 13896
    DOI: 10.1039/C4CC06200K

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