Issue 83, 2014
From the journal:

Chemical Communications

Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines†

Mu-Wang Chen,a   Xian-Feng Cai,a   Zhang-Pei Chen,a   Lei Shia  and  Yong-Gui Zhou*a  

* Corresponding authors

a State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
E-mail: ygzhou@dicp.ac.cn
Web: http://www.lac.dicp.ac.cn/

Abstract

An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.

Graphical abstract: Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

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Article information

DOI
https://doi.org/10.1039/C4CC06060A
Article type
Communication
Submitted
03 Aug 2014
Accepted
29 Aug 2014
First published
29 Aug 2014

Chem. Commun., 2014,50, 12526-12529

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Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

M. Chen, X. Cai, Z. Chen, L. Shi and Y. Zhou, Chem. Commun., 2014, 50, 12526 DOI: 10.1039/C4CC06060A

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