Issue 83, 2014
From the journal:

Chemical Communications

An NIR-responsive and sugar-targeted polypeptide composite nanomedicine for intracellular cancer therapy†

Gang Liu,a   Linzhu Zhou,a   Yue Sua  and  Chang-Ming Dong*a  

* Corresponding authors

a School of Chemistry & Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China
E-mail: cmdong@sjtu.edu.cn
Fax: +86-21-54741297
Tel: +86-21-54748916

Abstract

The upconversion nanoparticle (UCNP)-loaded polypeptide composite nanoparticles that present fast NIR-sensitivity and tunable sugar-targeting properties are fabricated, opening a new avenue for on-demand and targeted cancer therapy. The half maximal inhibitory concentration (IC50) of the nanoparticles dropped 4.7-fold or 3.1-fold compared to non-targeted or non-irradiated counterparts.

Graphical abstract: An NIR-responsive and sugar-targeted polypeptide composite nanomedicine for intracellular cancer therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC05983B
Article type
Communication
Submitted
31 Jul 2014
Accepted
02 Sep 2014
First published
02 Sep 2014

Chem. Commun., 2014,50, 12538-12541

Author version available

Download author version (PDF)

Permissions

Request permissions

An NIR-responsive and sugar-targeted polypeptide composite nanomedicine for intracellular cancer therapy

G. Liu, L. Zhou, Y. Su and C. Dong, Chem. Commun., 2014, 50, 12538 DOI: 10.1039/C4CC05983B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements