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Issue 96, 2014
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Diastereoselective synthesis of α-(aminomethyl)-γ-butyrolactones via a catalyst-free aminolactonization

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Abstract

An auto-catalytic domino reaction, presumably involving an aza-Michael reaction, proton transfer, and lactonization, furnishing α-(aminomethyl)-γ-butyrolactones in near quantitative yields and excellent diastereoselectivity is described.

Graphical abstract: Diastereoselective synthesis of α-(aminomethyl)-γ-butyrolactones via a catalyst-free aminolactonization

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Article information


Submitted
24 Jul 2014
Accepted
09 Oct 2014
First published
09 Oct 2014

Chem. Commun., 2014,50, 15216-15219
Article type
Communication
Author version available

Diastereoselective synthesis of α-(aminomethyl)-γ-butyrolactones via a catalyst-free aminolactonization

P. V. Ramachandran and D. R. Nicponski, Chem. Commun., 2014, 50, 15216
DOI: 10.1039/C4CC05765A

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