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Issue 78, 2014
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A multimeric MR-optical contrast agent for multimodal imaging

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Abstract

We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.

Graphical abstract: A multimeric MR-optical contrast agent for multimodal imaging

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Article information


Submitted
21 Jul 2014
Accepted
14 Aug 2014
First published
14 Aug 2014

Chem. Commun., 2014,50, 11469-11471
Article type
Communication
Author version available

A multimeric MR-optical contrast agent for multimodal imaging

V. S. R. Harrison, C. E. Carney, K. W. Macrenaris and T. J. Meade, Chem. Commun., 2014, 50, 11469
DOI: 10.1039/C4CC05651E

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