Jump to main content
Jump to site search

Issue 85, 2014

The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin–heparin complex

Author affiliations

Abstract

The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.

Graphical abstract: The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin–heparin complex

Supplementary files

Article information


Submitted
05 Jul 2014
Accepted
22 Aug 2014
First published
02 Sep 2014

Chem. Commun., 2014,50, 12966-12969
Article type
Communication
Author version available

The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin–heparin complex

K. J. Yeo, E. Hwang, K. Min, J. Jee, C. Lee, K. Y. Hwang, Y. H. Jeon, S. Chang and H. Cheong, Chem. Commun., 2014, 50, 12966 DOI: 10.1039/C4CC05175K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements