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Issue 88, 2014
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A domino desulfurative coupling–acylation–hydration–Michael addition process for the synthesis of polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines

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Abstract

A novel method for the synthesis of the polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines through a domino desulfurative coupling–acylation–hydration and Michael addition sequence was established.

Graphical abstract: A domino desulfurative coupling–acylation–hydration–Michael addition process for the synthesis of polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines

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Article information


Submitted
03 Jul 2014
Accepted
03 Sep 2014
First published
05 Sep 2014

Chem. Commun., 2014,50, 13555-13558
Article type
Communication

A domino desulfurative coupling–acylation–hydration–Michael addition process for the synthesis of polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines

Z. Yan, Z. Quan, Y. Da, Z. Zhang and X. Wang, Chem. Commun., 2014, 50, 13555
DOI: 10.1039/C4CC05090H

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