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Issue 97, 2014
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A mitochondria-targeted protonophoric uncoupler derived from fluorescein

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Abstract

Linking decyl-triphenyl-phosphonium to fluorescein yields a fluorescent probe that accumulates in energized mitochondria, facilitates proton transfer across membranes and stimulates mitochondrial respiration. This features a mitochondria-targeted uncoupler, being of potential interest for therapeutic use against oxidative stress-related diseases.

Graphical abstract: A mitochondria-targeted protonophoric uncoupler derived from fluorescein

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Article information


Submitted
03 Jul 2014
Accepted
16 Oct 2014
First published
16 Oct 2014

Chem. Commun., 2014,50, 15366-15369
Article type
Communication

A mitochondria-targeted protonophoric uncoupler derived from fluorescein

S. S. Denisov, E. A. Kotova, E. Y. Plotnikov, A. A. Tikhonov, D. B. Zorov, G. A. Korshunova and Y. N. Antonenko, Chem. Commun., 2014, 50, 15366
DOI: 10.1039/C4CC04996A

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