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Issue 79, 2014
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A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

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Abstract

We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1.

Graphical abstract: A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

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Publication details

The article was received on 27 Jun 2014, accepted on 08 Aug 2014 and first published on 08 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC04915B
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Chem. Commun., 2014,50, 11672-11675

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    A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

    Z. Yang, Y. He, J. H. Lee, W. Chae, W. X. Ren, J. H. Lee, C. Kang and J. S. Kim, Chem. Commun., 2014, 50, 11672
    DOI: 10.1039/C4CC04915B

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