An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF2CO2Et at ambient temperature†
Abstract
A mild, versatile and efficient method for the regioselective hydrodifluoromethylation of unactivated alkenes has been developed. This Ag-mediated Csp3–CF2 bond forming reaction provides easy access to a variety of vicinal α-difluoroacetate-containing alkanes.