GdF3 as a promising phosphopeptide affinity probe and dephospho-labelling medium: experiments and theoretical explanation

Abstract

Bone-like GdF₃ was synthesized and applied for phosphopeptide enrichment for the first time. As a new kind of efficient phosphopeptide affinity probe, GdF₃ exhibits high efficiency in the mediation of the dephosphorylation reaction. In addition, DFT calculations were introduced to theoretically explain the unique property of GdF₃ compared to GdPO₄, which is promising and can be potentially significant in protein phosphorylation research.