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Issue 64, 2014
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Enantioselective hydrogenation of α,β-disubstituted nitroalkenes

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Abstract

The first highly chemo- and enantioselective hydrogenation of α,β-disubstituted nitroalkenes was accomplished with rhodium/JosiPhos-J2 as a catalyst, with the yield and enantioselectivity of up to 95% and 94%, respectively. The α-chiral nitroalkanes will provide an entry to valuable chiral amphetamines which are otherwise not so easily accessed.

Graphical abstract: Enantioselective hydrogenation of α,β-disubstituted nitroalkenes

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Article information


Submitted
23 May 2014
Accepted
16 Jun 2014
First published
16 Jun 2014

Chem. Commun., 2014,50, 8878-8881
Article type
Communication

Enantioselective hydrogenation of α,β-disubstituted nitroalkenes

S. Li, K. Huang and X. Zhang, Chem. Commun., 2014, 50, 8878
DOI: 10.1039/C4CC03942D

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