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Issue 67, 2014
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Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

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Abstract

A purpose-designed porphyrin–peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.

Graphical abstract: Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

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Publication details

The article was received on 19 May 2014, accepted on 04 Jul 2014 and first published on 07 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03791J
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Chem. Commun., 2014,50, 9543-9546

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    Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

    A. Hirabayashi, Y. Shindo, K. Oka, D. Takahashi and K. Toshima, Chem. Commun., 2014, 50, 9543
    DOI: 10.1039/C4CC03791J

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