Jump to main content
Jump to site search

Issue 78, 2014
Previous Article Next Article

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

Author affiliations

Abstract

In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label plaques and cerebral amyloid angiopathies (CAAs). We also demonstrated that this imaging probe could inhibit the crosslinking of amyloid beta induced either by copper or by natural conditions.

Graphical abstract: A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

Back to tab navigation

Supplementary files

Article information


Submitted
16 May 2014
Accepted
22 Jul 2014
First published
06 Aug 2014

Chem. Commun., 2014,50, 11550-11553
Article type
Communication
Author version available

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

X. Zhang, Y. Tian, P. Yuan, Y. Li, M. A. Yaseen, J. Grutzendler, A. Moore and C. Ran, Chem. Commun., 2014, 50, 11550
DOI: 10.1039/C4CC03731F

Social activity

Search articles by author

Spotlight

Advertisements