Issue 63, 2014
From the journal:

Chemical Communications

A novel nanogel-based fluorescent probe for ratiometric detection of intracellular pH values†

Lixia Cao,a   Xiaoyan Li,a   Shuangqing Wang,a   Shayu Li,*a   Yi Li*b  and  Guoqiang Yang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: gqyang@iccas.ac.cn, shayuli@iccas.ac.cn

b Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: yili@mail.ipc.ac.cn

Abstract

A new nanogel indicator (NGI) for ratiometric fluorescent detection of intracellular pH values has been reported. In aqueous solution, the NGI can be used for ratiometric sensing of pH changes with a large hypsochromic shift of 100 nm in the green–red region and reversible. Furthermore, the NGI has been used to calibrate the cytosol pH value in living cells.

Graphical abstract: A novel nanogel-based fluorescent probe for ratiometric detection of intracellular pH values

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Article information

DOI
https://doi.org/10.1039/C4CC03716B
Article type
Communication
Submitted
15 May 2014
Accepted
20 Jun 2014
First published
20 Jun 2014

Chem. Commun., 2014,50, 8787-8790

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A novel nanogel-based fluorescent probe for ratiometric detection of intracellular pH values

L. Cao, X. Li, S. Wang, S. Li, Y. Li and G. Yang, Chem. Commun., 2014, 50, 8787 DOI: 10.1039/C4CC03716B

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