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Issue 60, 2014
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Differences in heterocycle basicity distinguish homocysteine from cysteine using aldehyde-bearing fluorophores

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Abstract

We report the detection of homocysteine over cysteine based upon characteristic differences between 5- and 6-membered heterocyclic amines formed upon reaction with aldehyde-bearing compounds. Homocysteine-derived thiazinane-4-carboxylic acids are more basic than cysteine-derived thiazolidines-4-carboxylic acids. Fluorescence enhancement in response to homocysteine is achieved by tuning pH and excitation wavelength.

Graphical abstract: Differences in heterocycle basicity distinguish homocysteine from cysteine using aldehyde-bearing fluorophores

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Publication details

The article was received on 10 May 2014, accepted on 10 Jun 2014 and first published on 10 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03527E
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Chem. Commun., 2014,50, 8219-8222

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    Differences in heterocycle basicity distinguish homocysteine from cysteine using aldehyde-bearing fluorophores

    A. Barve, M. Lowry, J. O. Escobedo, K. T. Huynh, L. Hakuna and R. M. Strongin, Chem. Commun., 2014, 50, 8219
    DOI: 10.1039/C4CC03527E

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