Issue 60, 2014
From the journal:

Chemical Communications

Robust detection of tyrosine phosphatase activity by coupling chymotrypsin-assisted selective peptide cleavage and a graphene oxide-based fluorescent platform†

Fangfang Wang,a   Chenghui Liu,*ab   Yunlong Fan,a   Yucong Wanga  and  Zhengping Li*ab  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei Province, P. R. China

b Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, Shaanxi Province, P. R. China
E-mail: liuch@snnu.edu.cn, lzpbd@snnu.edu.cn
Fax: +86 29 81530859

Abstract

A versatile graphene oxide (GO)-based fluorescent assay is developed for the detection of protein tyrosine phosphatase activity by coupling with a chymotrypsin-assisted selective peptide cleavage reaction.

Graphical abstract: Robust detection of tyrosine phosphatase activity by coupling chymotrypsin-assisted selective peptide cleavage and a graphene oxide-based fluorescent platform

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Article information

DOI
https://doi.org/10.1039/C4CC03498H
Article type
Communication
Submitted
09 May 2014
Accepted
04 Jun 2014
First published
04 Jun 2014

Chem. Commun., 2014,50, 8161-8163

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Robust detection of tyrosine phosphatase activity by coupling chymotrypsin-assisted selective peptide cleavage and a graphene oxide-based fluorescent platform

F. Wang, C. Liu, Y. Fan, Y. Wang and Z. Li, Chem. Commun., 2014, 50, 8161 DOI: 10.1039/C4CC03498H

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