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Issue 72, 2014
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DABCO-catalyzed ring opening of activated cyclopropanes and recyclization leading to γ-lactams with an all-carbon quaternary center

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Abstract

A novel and efficient method for the construction of γ-lactams with an all-carbon quaternary center is developed via a DABCO-catalyzed reaction of EWG-activated cyclopropanecarboxamides and electron-deficient alkenes. The process involves sequential ring-opening of activated cyclopropanes, intermolecular Michael addition and intramolecular aza-cyclization.

Graphical abstract: DABCO-catalyzed ring opening of activated cyclopropanes and recyclization leading to γ-lactams with an all-carbon quaternary center

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Publication details

The article was received on 06 May 2014, accepted on 11 Jul 2014 and first published on 22 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03392B
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Chem. Commun., 2014,50, 10491-10494

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    DABCO-catalyzed ring opening of activated cyclopropanes and recyclization leading to γ-lactams with an all-carbon quaternary center

    S. Lin, L. Li, F. Liang and Q. Liu, Chem. Commun., 2014, 50, 10491
    DOI: 10.1039/C4CC03392B

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