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Issue 90, 2014
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Synthetic turn mimetics and hairpin nucleators: Quo Vadimus?

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Abstract

Structural mimicry of peptides has witnessed perceptible progress in the last three decades. Reverse turn and β-hairpin units are the smallest secondary structural motifs that are some of the most scrutinized functional cores of peptides and proteins. The practice of mimicking, without altering the function of the bioactive core, ranges from conformational locking of the basic skeleton to total replacement of structural architecture using synthetic analogues. Development of heterogeneous backbones – using unnatural residues in place of natural ones – has broadened further opportunities for efficient structural rigidification. This feature article endeavours to trail the path of progress achieved hitherto and envisage the possibilities that lie ahead in the development of synthetic turn mimetics and hairpin nucleators.

Graphical abstract: Synthetic turn mimetics and hairpin nucleators: Quo Vadimus?

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Publication details

The article was received on 27 Apr 2014, accepted on 11 Jul 2014 and first published on 15 Jul 2014


Article type: Feature Article
DOI: 10.1039/C4CC03114H
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Chem. Commun., 2014,50, 13874-13884

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    Synthetic turn mimetics and hairpin nucleators: Quo Vadimus?

    R. V. Nair, S. B. Baravkar, T. S. Ingole and G. J. Sanjayan, Chem. Commun., 2014, 50, 13874
    DOI: 10.1039/C4CC03114H

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