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Issue 94, 2014
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Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells

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Abstract

We achieved single-molecule imaging and tracking of the transforming growth factor type II receptor (TβRII) that was labeled by an organic dye via a genetically encoded unnatural amino acid (UAA) and the copper-free click chemistry. The stoichiometry, mobility and dimerization kinetics of individual TβRII molecules were determined.

Graphical abstract: Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells

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Article information


Submitted
16 Apr 2014
Accepted
15 May 2014
First published
19 May 2014

Chem. Commun., 2014,50, 14724-14727
Article type
Communication
Author version available

Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells

M. Cheng, W. Zhang, J. Yuan, W. Luo, N. Li, S. Lin, Y. Yang, X. Fang and P. R. Chen, Chem. Commun., 2014, 50, 14724
DOI: 10.1039/C4CC02804J

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