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Issue 56, 2014
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Glycoligand-targeted core–shell nanospheres with tunable drug release profiles from calixarene–cyclodextrin heterodimers

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Abstract

Stable core–shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a hydrophilic β-cyclodextrin head; their potential to encapsulate and provide sustained release of the anticancer drug docetaxel and undergo surface post-modification with glycoligands targeting the macrophage mannose receptor is discussed.

Graphical abstract: Glycoligand-targeted core–shell nanospheres with tunable drug release profiles from calixarene–cyclodextrin heterodimers

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Supplementary files

Article information


Submitted
11 Apr 2014
Accepted
15 May 2014
First published
19 May 2014

Chem. Commun., 2014,50, 7440-7443
Article type
Communication
Author version available

Glycoligand-targeted core–shell nanospheres with tunable drug release profiles from calixarene–cyclodextrin heterodimers

L. Gallego-Yerga, M. Lomazzi, F. Sansone, C. Ortiz Mellet, A. Casnati and J. M. García Fernández, Chem. Commun., 2014, 50, 7440
DOI: 10.1039/C4CC02703E

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