Issue 57, 2014
From the journal:

Chemical Communications

A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis†

Jung Min Shin,‡a   Seol-Hee Kim,‡bc   Thavasyappan Thambi,a   Dong Gil You,a   Jueun Jeon,a   Jong Oh Lee,d   Bong Youl Chung,d   Dong-Gyu Jo*be  and  Jae Hyung Park*ae  

* Corresponding authors

a School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: jhpark1@skku.edu
Fax: +82-31-299-6857
Tel: +82-31-290-7288

b School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: jodg@skku.edu
Fax: +82-31-292-8800
Tel: +82-31-290-7776

c Center of Bioanalysis, Korea Research Institute of Standards and Science, Daejeon 305-340, Republic of Korea

d Humedix, Co., Ltd., Megavalley 401, Haguiro, Dongangu, Anyang 431-767, Republic of Korea

e Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Suwon 440-746, Republic of Korea

Abstract

In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid–MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.

Graphical abstract: A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

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Article information

DOI
https://doi.org/10.1039/C4CC02595D
Article type
Communication
Submitted
08 Apr 2014
Accepted
16 May 2014
First published
20 May 2014

Chem. Commun., 2014,50, 7632-7635

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A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

J. M. Shin, S. Kim, T. Thambi, D. G. You, J. Jeon, J. O. Lee, B. Y. Chung, D. Jo and J. H. Park, Chem. Commun., 2014, 50, 7632 DOI: 10.1039/C4CC02595D

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