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Issue 95, 2014
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Practical fluorescence detection of acrolein in human plasma via a two-step tethering approach

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Abstract

Acrolein, a cytotoxic α,β-unsaturated aldehyde and disease biomarker, was determined in plasma by means of a novel tethering strategy using Michael addition of the compound to a fluorescent dye, followed by immobilization of the product on microbeads via the aldehyde moiety. Elevation of blood acrolein was detected in mice treated with an anticancer agent cyclophosphamide, which releases acrolein upon activation. This method should be suitable for high-throughput diagnostic and clinical application.

Graphical abstract: Practical fluorescence detection of acrolein in human plasma via a two-step tethering approach

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Article information


Submitted
08 Apr 2014
Accepted
09 Jun 2014
First published
19 Jun 2014

Chem. Commun., 2014,50, 14946-14948
Article type
Communication

Practical fluorescence detection of acrolein in human plasma via a two-step tethering approach

M. Togashi, T. Terai, H. Kojima, K. Hanaoka, K. Igarashi, Y. Hirata, Y. Urano and T. Nagano, Chem. Commun., 2014, 50, 14946
DOI: 10.1039/C4CC02578D

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