Jump to main content
Jump to site search

Issue 53, 2014
Previous Article Next Article

A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off–on fluorescent probe for covalent labelling of thioredoxin reductase

Author affiliations

Abstract

A simple and novel furanyl acryl conjugated coumarin fluorophore was designed as an effective thioredoxin reductase (TrxR)-responding fluorescent probe by an activity-guided approach. Basically, the α,β-unsaturated ketone moiety in the probe structure could quench the fluorescence of the coumarin, but upon the covalent modification of TrxR, a significant fluorescence could be generated, which has been confirmed to be obviously selective over Trx, GSH, Cys and DTT.

Graphical abstract: A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off–on fluorescent probe for covalent labelling of thioredoxin reductase

Back to tab navigation

Supplementary files

Article information


Submitted
21 Mar 2014
Accepted
08 May 2014
First published
08 May 2014

Chem. Commun., 2014,50, 6987-6990
Article type
Communication

A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off–on fluorescent probe for covalent labelling of thioredoxin reductase

L. Huang, Y. Chen, B. Liang, B. Xing, G. Wen, S. Wang, X. Yue, C. Zhu, J. Du and X. Bu, Chem. Commun., 2014, 50, 6987
DOI: 10.1039/C4CC02119C

Social activity

Search articles by author

Spotlight

Advertisements