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Issue 38, 2014
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Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

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Abstract

Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism.

Graphical abstract: Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

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Publication details

The article was received on 17 Mar 2014, accepted on 27 Mar 2014 and first published on 31 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC02003K
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Chem. Commun., 2014,50, 4944-4946

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    Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

    M. Kamalov, P. W. R. Harris, G. J. S. Cooper and M. A. Brimble, Chem. Commun., 2014, 50, 4944
    DOI: 10.1039/C4CC02003K

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