Issue 51, 2014
From the journal:

Chemical Communications

An ensemble of aptamers and antibodies for multivalent capture of cancer cells†

Jinling Zhang,a   Weian Shenga  and  Z. Hugh Fan*abc  

* Corresponding authors

a Interdisciplinary Microsystems Group, Department of Mechanical and Aerospace Engineering, University of Florida, PO Box 116250, Gainesville, Florida 32611, USA
E-mail: hfan@ufl.edu
Fax: +1 352 392 7303
Tel: +1 352 846 3021

b J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, P.O. Box 116131, Gainesville, FL 32611, USA

c Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL 32611, USA

Abstract

We developed an optimized ensemble of aptamers and antibodies that functions as a multivalent adhesive domain for the capture and isolation of cancer cells. When incorporated into a microfluidic device, the ensemble showed not only high capture efficiency, but also superior capture selectivity at a high shear stress (or high flow rate).

Graphical abstract: An ensemble of aptamers and antibodies for multivalent capture of cancer cells

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Article information

DOI
https://doi.org/10.1039/C4CC02002B
Article type
Communication
Submitted
17 Mar 2014
Accepted
30 Apr 2014
First published
02 May 2014

Chem. Commun., 2014,50, 6722-6725

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An ensemble of aptamers and antibodies for multivalent capture of cancer cells

J. Zhang, W. Sheng and Z. H. Fan, Chem. Commun., 2014, 50, 6722 DOI: 10.1039/C4CC02002B

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