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Issue 56, 2014
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A genetically encoded aldehyde for rapid protein labelling

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Abstract

Using a mutant pyrrolysyl-tRNA synthetase-tRNAPylCUA pair, 3-formyl-phenylalanine is genetically incorporated into proteins at amber mutation sites in Escherichia coli. This non-canonical amino acid readily reacts with hydroxylamine dyes, leading to rapid and site-selective protein labelling.

Graphical abstract: A genetically encoded aldehyde for rapid protein labelling

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Supplementary files

Article information


Submitted
17 Mar 2014
Accepted
04 Apr 2014
First published
09 Apr 2014

Chem. Commun., 2014,50, 7424-7426
Article type
Communication
Author version available

A genetically encoded aldehyde for rapid protein labelling

A. Tuley, Y. Lee, B. Wu, Z. U. Wang and W. R. Liu, Chem. Commun., 2014, 50, 7424
DOI: 10.1039/C4CC02000F

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