Issue 62, 2014
From the journal:

Chemical Communications

From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins†

S. Desrat,a   C. Remeur,a   C. Gény,a   G. Rivière,a   C. Colas,a   V. Dumontet,a   N. Birlirakis,a   B. I. Iorgaa  and  F. Roussi*a  

* Corresponding authors

a Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles (ICSN), CNRS UPR 2301, 1 av de la Terrasse, 91 198 Gif-sur-Yvette Cedex, France
E-mail: fanny.roussi@cnrs.fr

Abstract

The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.

Graphical abstract: From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

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Article information

DOI
https://doi.org/10.1039/C4CC01830C
Article type
Communication
Submitted
11 Mar 2014
Accepted
08 Jun 2014
First published
11 Jun 2014

Chem. Commun., 2014,50, 8593-8596

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From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

S. Desrat, C. Remeur, C. Gény, G. Rivière, C. Colas, V. Dumontet, N. Birlirakis, B. I. Iorga and F. Roussi, Chem. Commun., 2014, 50, 8593 DOI: 10.1039/C4CC01830C

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