Issue 46, 2014

An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones

Abstract

We disclose a novel efficient enantioselective organocatalytic cascade reaction for the preparation of δ-lactones in good to excellent yields (69–93%) and with high to excellent enantioselectivities (88–96% ee).

Graphical abstract: An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones

Supplementary files

Article information

Article type
Communication
Submitted
07 Mar 2014
Accepted
15 Apr 2014
First published
15 Apr 2014

Chem. Commun., 2014,50, 6137-6140

Author version available

An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones

Q. Ren, S. Sun, J. Huang, W. Li, M. Wu, H. Guo and J. Wang, Chem. Commun., 2014, 50, 6137 DOI: 10.1039/C4CC01736F

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