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Issue 49, 2014
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TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

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Abstract

Cationic oligomers with a rigid aromatic backbone were first applied as non-viral gene delivery vectors. These materials showed better DNA condensation ability than their flexible analogues. In vitro transfection experiments revealed that the materials with more rigid backbone exhibited considerably higher TE and lower cytotoxicity than 25 kDa PEI.

Graphical abstract: TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

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Supplementary files

Article information


Submitted
16 Feb 2014
Accepted
27 Mar 2014
First published
27 Mar 2014

Chem. Commun., 2014,50, 6454-6457
Article type
Communication
Author version available

TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

W. Yi, X. Yu, B. Wang, J. Zhang, Q. Yu, X. Zhou and X. Yu, Chem. Commun., 2014, 50, 6454
DOI: 10.1039/C4CC01210K

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