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Issue 57, 2014
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Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies

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Abstract

A self-assembled nanoparticle containing a photosensitizer and a Trojan-horse moiety (cholesterol), binds an anti-TB pro-drug and increases 1000-fold its activity against mycobacteria. These minimalist constructs will allow development of economically viable, efficient drug preparations for the treatment of drug-resistant TB infections.

Graphical abstract: Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies

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Publication details

The article was received on 15 Jan 2014, accepted on 22 May 2014 and first published on 22 May 2014


Article type: Communication
DOI: 10.1039/C4CC00349G
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Chem. Commun., 2014,50, 7649-7651

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    Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies

    M. Bhatti, T. D. McHugh, L. Milanesi and S. Tomas, Chem. Commun., 2014, 50, 7649
    DOI: 10.1039/C4CC00349G

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