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Issue 25, 2014
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Palladium-catalyzed synthesis of benzofurans via C–H activation/oxidation tandem reaction and its application to the synthesis of decursivine and serotobenine

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Abstract

A new palladium-catalyzed method for the synthesis of benzofurans by reaction of 2-hydroxystyrenes and iodobenzenes via a C–H activation/oxidation tandem reaction has been unprecedentedly discovered. By using this strategy, the overall synthetic efficiency of the synthesis of decursivine and its analogues was indeed improved. Preliminary mechanistic studies shed light into the possible mechanisms.

Graphical abstract: Palladium-catalyzed synthesis of benzofurans via C–H activation/oxidation tandem reaction and its application to the synthesis of decursivine and serotobenine

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Publication details

The article was received on 23 Dec 2013, accepted on 24 Jan 2014 and first published on 07 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC49717H
Citation: Chem. Commun., 2014,50, 3299-3302
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    Palladium-catalyzed synthesis of benzofurans via C–H activation/oxidation tandem reaction and its application to the synthesis of decursivine and serotobenine

    L. Guo, F. Zhang, W. Hu, L. Li and Y. Jia, Chem. Commun., 2014, 50, 3299
    DOI: 10.1039/C3CC49717H

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