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Issue 19, 2014
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Iridium-catalyzed selective α-methylation of ketones with methanol

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Abstract

Iridium-catalyzed selective α-dimethylation and α-methylation of ketones or phenylacetonitriles, using methanol as the methylating agent, were achieved. In addition, three-component cross α-methyl-alkylation was successfully performed using methyl ketones with methanol and primary alcohols with long-chain alkyl groups. This method provides a very convenient direct route to α-methylated ketones, using methanol.

Graphical abstract: Iridium-catalyzed selective α-methylation of ketones with methanol

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Supplementary files

Article information


Submitted
19 Dec 2013
Accepted
14 Jan 2014
First published
15 Jan 2014

Chem. Commun., 2014,50, 2491-2493
Article type
Communication
Author version available

Iridium-catalyzed selective α-methylation of ketones with methanol

S. Ogawa and Y. Obora, Chem. Commun., 2014, 50, 2491
DOI: 10.1039/C3CC49626K

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