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Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria†
Abstract
Cox17 facilitates the platinum accumulation in mitochondria, which contributes to the overall cytotoxicity of cisplatin.
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Article information
- Article type
- Communication
- Submitted
- 20 Nov 2013
- Accepted
- 19 Jan 2014
- First published
- 20 Jan 2014
Chem. Commun., 2014,50, 2667-2669
Author version available
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Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria
L. Zhao, Q. Cheng, Z. Wang, Z. Xi, D. Xu and Y. Liu, Chem. Commun., 2014, 50, 2667 DOI: 10.1039/C3CC48847K
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